Eoin Griffin makes his return to the starting line-up at outside centre, as does Rob Herring who is named at hooker.
David O'Callaghan joins fellow Munsterman David Foley in the second row and number 8 Eoin McKeon makes his first start of the tournament in place of Robbie Diack, who is unavailable due to a calf injury.
Sunday's match will be streamed live on the IRB website, and sees the Irish youngsters bidding to end the competition on a winning note.
Emerging Ireland are third in the standings on four points - a point behind hosts Georgia, who face the table-topping South Africans in the final round. Uruguay are bottom and without a point after losing to the South Africans (37-9) and Georgia (27-3).
EMERGING IRELAND Team & Replacements (v Uruguay, IRB Tbilisi Cup, Avchala Stadium, Tbilisi, Sunday, June 16, kick-off 4pm local time/1pm Irish time):
15 - David Kearney (Lansdowne/Leinster) *
14 - Niall Morris (Leicester Tigers/Exile) *
13 - Eoin Griffin (Galwegians/Connacht) *
12 - Noel Reid (Clontarf/Leinster) *
11 - Tiernan O'Halloran (Galwegians/Connacht) *
10 - Ian Keatley (Young Munster/Munster)
9 - John Cooney (Lansdowne/Leinster) *
1 - Jack McGrath (St. Mary's College/Leinster) *
2 - Rob Herring (Ballynahinch/Ulster) *
3 - Michael Bent (Leinster)
4 - David O'Callaghan (Dolphin/Munster) *
5 - David Foley (UL Bohemians/Munster) *
6 - Rhys Ruddock (St. Mary's College/Leinster) (capt)
7 - Jordi Murphy (Lansdowne/Leinster) *
8 - Eoin McKeon (Galwegians/Connacht) *
16 - Niall Annett (Belfast Harlequins/Ulster) *
17 - Richard Lutton (Belfast Harlequins/Ulster) *
18 - Ian Nagle (Cork Constitution/Munster) *
19 - Dominic Ryan (Lansdowne/Leinster) *
20 - Michael Heaney (Belfast Harlequins/Ulster) *
21 - Brendan Macken (Blackrock College/Leinster) *
22 - Peter Nelson (Dungannon/Ulster) *
* Denotes uncapped player
EMERGING IRELAND RESULTS/FIXTURES - IRB TBILISI CUP:
Friday, June 7: Georgia 15 Emerging Ireland 20, Avchala Stadium
Tuesday, June 11: Emerging Ireland 8 South Africa President's XV 19, Avchala Stadium
Sunday, June 16: Uruguay v Emerging Ireland, Avchala Stadium, 4pm local time/1pm Irish time